On April 2, 2026, under the supervision of Khamida Rakhimovna Abdikadirova, Candidate of Medical Sciences and Professor of the “Pathologic Physiology” block of the Department of Physiology, an experimental research on laboratory rats was conducted, along with a round table discussion dedicated to the importance of experiment in medicine (RBL — Research-Based Learning).The event involved students from group 2-003 of the School of Dentistry and group 3013 of the School of Medicine, with the purpose of integrating education and science.

The goal of the research was to evaluate the effects of caffeine on glucose levels in blood, as well as on the central nervous, cardiovascular, and respiratory systems. In addition, a comprehensive study was carried out on the effects of cardiac medications, adrenaline, and diuretic medications on the body.

During the experiment, acute activation of the sympathoadrenal system and hyperglycemic condition were modeled. Under the influence of caffeine and adrenaline, increases in heart rate, changes in arterial blood pressure, and variations in breathing patterns were observed. The cardiotropic effects of cardiac medications were evaluated, and their impact on myocardial activity was analyzed. Changes in the body's salt and water metablosim were examined through increased urine formation (increased diuresis). This phenomenon demonstrated the important function of the kidneys in regulating hemodynamics and homeostasis.

Special attention has been given to the effects of high doses of adrenaline and their impact on hemodynamic changes in lung tissue. In particular, it was demonstrated that under the influence of adrenaline in response to the increase in hydrostatic pressure in pulmonary capillaries and changes in pulmonary edema can develop. This condition was interpreted as a pathophysiological process closely associated with acute cardiac failure and disturbed circulation.

The conducted research allowed for a comprehensive evaluation of the pharmacodynamic effects of medicinal products, and can serve as a basis for testing antihyperglycemic, cardiotropic, and anxiolytic drugs, as well as for preparation stages of research in neuropharmacology, cardiology, and endocrinology. The experiment enabled students to gain a better understanding in practice of the interaction between pathophysiological processes and pharmacological effects, while also developing their laboratory and analytical skills. This, in turn, contributes to the development of scientific thinking and enhances the professional competencies of prospective specialists.

Active involvement of students in research activities strengthens the integration of education and science in the field of medicine and serves as a basis for the development of professional competencies in future specialists. We wish them high performance and success in advancing education and science in this field and express our sincere gratitude for the work accomplished.